Curcumin to cure Cancer Research Paper Example | Topics and Well Written Essays - 500 words

Curcumin to cure Cancer - Research writing Exampleies have been performed that hold up curcumin-mediated regulation of coxswain pathways, which is an essential mechanism by which curcumin pelf a number of ailment processes, including the cancer. The precise regulation of COX-2 by curcumin is not fully establish though, existing evidence show that curcumin controls COX-2 mainly at the transcriptional level and, to some extent, the posttranslational level. The curcumin-selective transcriptional control exertion of the COX-2 inhibitory potential of this naturally occurring agent offer unique advantages over synthetic COX inhibitors, such as non-steroidal anti-inflammatory drugs.Cells provide be treated with free Cisplatin and then with free curcumin to see the effectivity of the chemotherapeutic drug. This control will be compared to a plate of cells treated with nano- capsulised curcumin along with cisplatin. My guessing is that the nanoparticle delivery of drugs will show less resistance in the cells to the chemopreventive drug, a down regulation of COX-2, as well as decreased proliferation. I will be using fluorescent mesoporoussilicananoparticles to encapsulate the cisplatin and deliver it to the mitochondria of the cells. The delivery system should not only demonstrate enhanced cellular uptake, but as well as show an elevateddrug effect which should reduce the associated side effects. In addition, a new, simple and more or less priced fluorescent based PT quantification technique has been adopted as an alternative of the mutually used ICP-based quantification rule and this strategy of quantification could be elaborated to monitor fluorescentpro drugnanoparticlesduring real-time diagnosis. A common problem with the present chemotherapeutic interventions is that it causes inflammation in the gut and kidney cells. To test my method against this, I will also conjugate the cisplatin nanoparticles with curcumin to test if the side effects are even furth er diminished. To measure the effectiveness of the